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Indeed, this extended release formulation has previously demonstrated significant pain relieve in a Phase III clinical trial involving patients with osteoarthritis of the knee. Overall Study Design and Plan The clinical trial was designed to evaluate the efficacy and Tramadol use safety of Biovail's extended release tramadol (once-daily) formulation in the treatment of chronic low back pain.
Combinations of agents are commonly used to control symptoms and provide synergistic analgesic effect, making the anticipation and prevention of side effects particularly challenging in patients with cancer.
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